Pengaruh Penambahan Propilen Glikol, Tween 80, Tween 20 dan PEG 400 Terhadap Kelarutan Furosemide

Rahmadevi Rahmadewi; auzal Halim; ayu Widyaningrum; Dwi Putri Septiani

Rahmadevi Rahmadewi Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi
auzal Halim Fakultas Farmasi Universitas Andalas, Padang
ayu Widyaningrum Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi
Dwi Putri Septiani Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Abstract

Abstract

Solubility of Active Pharmaceutical Ingredient is an important role in the formulation of a pharmaceutical preparation. Drugs that have a small solubility showed low bioavailability. Furosemide is a strong diuretic has a solubility value of 0,01 mg/ ml and log P 0,74 that are classified into the BCS (Biopharmaceutics Classification System) class 4, are a drug which has low solubility and low permeability. In this study, the addition of surfactants are P

Abstract

Solubility of Active Pharmaceutical Ingredient is an important role in the formulation of a pharmaceutical preparation. Drugs that have a small solubility showed low bioavailability. Furosemide is a strong diuretic has a solubility value of 0,01 mg/ ml and log P 0,74 that are classified into the BCS (Biopharmaceutics Classification System) class 4, are a drug which has low solubility and low permeability. In this study, the addition of surfactants are PEG 400, Tween 80, tween 20, and propilenglikol to increase the solubility of Furosemide. Each of these surfactants measured surface tension in order to get the point of the CMC to view the solubility of 10 mg of furosemide were measured by UV spectrophotometer. Results of the research that has been conducted on concentration obtained CMC point PEG 400, Tween 80, tween 20, and propilenglikol respectively from 0,19 to 0,22%; 0,2 to 0,22% and 6-8%. Based on these results an increase in the solubility of Furosemide.

Keywords : Solubilization, CMC point, FurosemideEG 400, Tween 80, tween 20, and propilenglikol to increase the solubility of Furosemide. Each of these surfactants measured surface tension in order to get the point of the CMC to view the solubility of 10 mg of furosemide were measured by UV spectrophotometer. Results of the research that has been conducted on concentration obtained CMC point PEG 400, Tween 80, tween 20, and propilenglikol respectively from 0,19 to 0,22%; 0,2 to 0,22% and 6-8%. Based on these results an increase in the solubility of Furosemide.

Keywords : Solubilization, CMC point, Furosemide