Histopathological study of renal hypertension with avocado leaf extract and fractional in male wistar rats

  • elisa Novi Stifar Yaphar Semarang
  • Yustisia Dian Advistasari
  • Jaka Sepriantor Lepangkari
  • Wulan Kartika Sari

Abstract

Background: The first of the cardiovascular diseases that may turn deadly is hypertension, which has elevated blood pressure. The causes of hypertension, which causes an average rise of 140/90 mmHg, are based on epidemiological factors such as stroke, heart failure, myocardial infarction, arterial fibrillation, and peripheral artery disease. Hypertension is also known as the silent killer.


Objective: Known histopathology in kidney cells and avocado leaf compounds that could potentially inhibit hypertension.


Methods: Methods that can be used in histopathological testing with hematoxylin and eosin (HE) dying and compound determination by analysis Gas Chromatography-Spectrometry Mass (GC-MS)


Results: The study obtained GC-MS (Gas Chromatography-Spectrometry Mass) analysis results at an area of 36.50%, molecular weight 17,03 with 9-Octadecenoic acid compounds, and an area of 10,18%, molécular weight 2,54 with a compound of 9-Oktadecenosic acid (z)-methyl esters (CAS).
An extract of 250 mg/kgBW has a slightly low renal cell damage value (138), and an effective avocado leaf fraction test is ethanol acetate 250 mg/kgBW, with a small renal cell damage value (146), where as a negative control has a high renal cell damage value (189).

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Author Biography

elisa Novi, Stifar Yaphar Semarang

Background: The first of the cardiovascular diseases that may turn deadly is hypertension, which has elevated blood pressure. The causes of hypertension, which causes an average rise of 140/90 mmHg, are based on epidemiological factors such as stroke, heart failure, myocardial infarction, arterial fibrillation, and peripheral artery disease. Hypertension is also known as the silent killer.

Objective: Known histopathology in kidney cells and avocado leaf compounds that could potentially inhibit hypertension.

Methods: Methods that can be used in histopathological testing with hematoxylin and eosin (HE) dying and compound determination by analysis Gas Chromatography-Spectrometry Mass (GC-MS)

Results: The study obtained GC-MS (Gas Chromatography-Spectrometry Mass) analysis results at an area of 36.50%, molecular weight 17,03 with 9-Octadecenoic acid compounds, and an area of 10,18%, molécular weight 2,54 with a compound of 9-Oktadecenosic acid (z)-methyl esters (CAS).
An extract of 250 mg/kgBW has a slightly low renal cell damage value (138), and an effective avocado leaf fraction test is ethanol acetate 250 mg/kgBW, with a small renal cell damage value (146), where as a negative control has a high renal cell damage value (189).

Published
2024-06-30
How to Cite
NOVI, elisa et al. Histopathological study of renal hypertension with avocado leaf extract and fractional in male wistar rats. Riset Informasi Kesehatan, [S.l.], v. 13, n. 1, p. 100-105, june 2024. ISSN 2548-6462. Available at: <https://jurnal.stikes-hi.ac.id/index.php/rik/article/view/823>. Date accessed: 22 july 2024. doi: https://doi.org/10.30644/rik.v13i1.823.

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