A Test of the effectiveness of the ethyl acetate fraction of dayak onion bulbs (eleutherine bulbosa (mill.) urb) as an antihypertensive

  • Putri Nilam Sari universitas fort de kock
  • Miming Andika 9Faculty of Pharmacy, University Fort De Kock
  • Evi Hasnita
  • Rizqa Hasanah
  • Oriza Sativa Fitriani
  • Fajrian Aulia Putra
  • Nola Rahmadasmi
  • Nanda Nanda
  • Tuti Handayani

Abstract

Hypertension is a condition where blood pressure exceeds normal limits, where systolic blood pressure is above 140 mmHg and diastolic blood pressure is above 90 mmHg. One plant that can lower blood pressure is Dayak onion bulbs. The aim of this study was to determine the effectiveness of the ethyl acetate fraction of Dayak onion bulbs (Eleutherine bulbosa (Mill) Urb) in reducing blood pressure in hypertensive male white rats. The method was experimental, using 36 male white rats, divided into 6 groups, namely negative control, positive control, dose group (50, 100, 200 mg/kgbb) and comparison group (catopril). The inducer used was 8% NaCl for 14 days. Blood pressure measurements are carried out using a Non-Invasive Blood Pressure (NIBP) device. Data analysis used One Way Anova and continued with the Duncan test. The results showed that administration of Dayak onion bulb ethyl acetate fraction had an effect on reducing systolic, diastolic, mean arterial blood pressure and heart rate significantly (p<0.05). The conclusion shows that the effective dose in reducing blood pressure is administration of the ethyl acetate fraction at a dose of 200 mg/kgbb. There was a histopathological improvement in the thickness of the left ventricular muscle in mice.

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Author Biography

Miming Andika, 9Faculty of Pharmacy, University Fort De Kock

Background: When blood pressure is higher than normal—that is, when the systolic and diastolic pressures are greater than 140 and 90 mmHg, respectively—it is referred to as hypertension. Dayak onion bulbs are one plant that can reduce blood pressure. This study sought to ascertain if the ethyl acetate component of Dayak onion bulbs (Eleutherine bulbosa (Mill) Urb) might effectively lower blood pressure in male white rats that were hypertensive.

Method: The study employed an experimental design with 36 male white rats split into 6 groups: dosage group (50, 100, 200 mg/kgbb), comparator group (catopril), negative control, and positive control. For 14 days, an 8% NaCl inducer was applied. A Non-Invasive Blood Pressure (NIBP) gadget is used to measure blood pressure. One Way Anova was utilized in the data analysis, and then the Duncan test was performed.

Results: The injection of Dayak onion bulb ethyl acetate fraction was found to have a substantial (p<0.05) reduction in systolic, diastolic, mean arterial blood pressure, and heart rate.

Conclusion: The analysis concludes that administering the ethyl acetate component at a dose of 200 mg/kgbb is the most effective way to lower blood pressure. The thickness of the left ventricle in mice showed a histological improvement.

Keywords: Antihypertensive; Dayak Onion Bulbs; Histopatholog

Published
2024-06-30
How to Cite
SARI, Putri Nilam et al. A Test of the effectiveness of the ethyl acetate fraction of dayak onion bulbs (eleutherine bulbosa (mill.) urb) as an antihypertensive. Riset Informasi Kesehatan, [S.l.], v. 13, n. 1, p. 82-92, june 2024. ISSN 2548-6462. Available at: <https://jurnal.stikes-hi.ac.id/index.php/rik/article/view/836>. Date accessed: 22 july 2024. doi: https://doi.org/10.30644/rik.v13i1.836.